Starting Monday, sections Roy Martin Road, located off state Highway 75, and Saylor Road, located off Hales Chapel Road, will be closed for the work.
County officials said the bridge work will impact a stretch between 308 to 370 of Roy Martin Road. The replacement of the bridge is expected to take 150 days.
A portion of Saylor Road, from 246 to 254, will also be closed while crews replace a bridge. The project is expected to take 90 days.