The Buccaneers broke away from a halftime tie in the third quarter, and then held on for a 61-56 decision over North Carolina A&T at Brooks Gym.
ETSU improved to 2-11 on the season.
After a tight first half, an early fourth-quarter basket by Erica Haynes-Overton gave ETSU its biggest lead at 48-35.
However, A&T moved within four points at 50-46 with 6:37 to go, and then whittled it to one point at 52-51 with 5:17 left.
A basket by C’coriea Foy put A&T ahead, but Lexus Spears scored to give ETSU a 54-53 advantage with 3:46 to go.
Haynes-Overton scored on the next possession and ETSU held on to the finish.
Carley Lytton stepped up big time for the Bucs. She drained six of eight attempts from 3-point land and finished with 19 points.
The 5-foot-11 junior also chipped in four assists and a pair of rebounds in a superb performance.
ETSU started strong, controlling the first quarter by a 15-8 margin.
Things got off track in the second quarter as a 6-0 run by A&T closed the difference to one point at 19-18. ETSU bumped back ahead by six points, but Rayven Peeples made a layup with 18 seconds to go in the period, eventually sending the teams into the locker room with a 25-25 tie.
Leading 34-31, ETSU took charge after a Lytton trey gave the Bucs a six-point edge. Lytton hit another three ball with 3:41 left in the third quarter to make it 40-33.
Britney Snowden followed with a basket, and the Bucs began to take command.
Haynes-Overton chipped in with 12 points while also adding three assists, three rebounds, and her typical high total of five steals.
Micah Sheetz was also in the mix, finishing with 10 points. Spears added six points and seven rebounds.
Peeples led the Aggies (2-7) with 18 points and 10 rebounds. Foy added 16 points while Charnise Tyler totaled 12 points and 11 rebounds.
ETSU travels to Pittsburgh to play Duquense on Sunday at 2:30 p.m.