The result broke a three-game losing skid for the Pirates (12-11) and ended a three-game win streak for rival Johnson City (13-9).
The Cardinals had opened this three-game road set with two well-pitched wins, but this time Bristol toted big lumber and avoided a sweep.
Third-place Bristol scored in bunches and turned the tables on the Cards, who still own a half-game lead over Elizabethton atop the Appy's West Division.
The BriBucs raked four Johnson City pitchers for a whopping 18 base hits, doing most of their damage against Cardinal starter Jose Moreno, a right-hander who was given ample opportunity to pitch through the tough times before eventually allowing seven runs and 11 hits in his four-plus innings of work.
"Sometimes they (base hits and runs) come in bunches, and we did nothing to slow them down tonight," said JC pitching coach Rick Harig. "They say hitting is contagious and sometimes it actually is.
"We're working on guys who have certain pitch counts, ya know, and we're about development. So it's a learning experience. Next time we'll do better."
Cardinal pitchers fooled no one, evidenced by the fact that Matt Morrow, Aaron Shackelford and Jose Medina collected three hits apiece, while Daniel Rivero, Ernny Ordonez and Ethan Goforth all had two hits each.
Morrow drove in three runs and scored three times as well. Ordonez also plated three runs, while Shackelford knocked in a pair.
Bristol fashioned 14 singles among its 18 hits, which included no home runs.
Johnson City barely threatened against three Bristol pitchers, beginning with starter Santiago Florez, who went 4 2/3 innings and left leading 7-0 to put reliever Trey McGough in fine position to scoop up the win. Closer Samson Abernathy earned a three-inning save with a perfect outing.
The Cardinals managed only four hits all night.
Johnson City travels tonight to begin a key four-game set at Elizabethton.