The action starts at 7 p.m. Gates open at 5:30 and admission is free. Concession stands on both sides of the stadium will be open.
It will be ETSU fans' last chance to see the team in action until preseason camp begins.
"It's always fun whenever the guys get to go out and compete and go against each other," ETSU defensive coordinator Billy Taylor said. "They're keeping score and we're going to make it as close to a game simulation as we can because a lot of times, whenever you put the lights on, you get to see a little bit different player."
New head coach Randy Sanders is on administrative leave and the team has no offensive coordinator after Marcus Satterfield abruptly left the program this week. In their absence, the offense will be run by wide receivers coach Mike Rader.
The game will feature four 15-minute quarters with a running clock that will stop in the final two minutes of each half.
"It's been a great 13 days so far," Taylor said after Tuesday's practice. "We've had a lot of young guys step up. It's been a physical spring. But the thing about spring ball is evaluating players. The big thing we want to do is come out of spring and evaluate all the film we've got, evaluate the players and come out with a two-deep that's going to go into for the first game next year.
The game is sponsored by Ballad Health